NB100-78365 PARP antibody

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Mouse anti Human, Mouse PARP 5A5


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  • NB100-78365
  • NB100-78365
  • NB100-78365

Product Description for PARP

Mouse anti Human, Mouse PARP 5A5.
Presentation: Biotin
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for PARP

Product Category Primary Antibodies
Quantity 0.25 mg
Synonyms ADP-ribose
Presentation Biotin
Reactivity Hu, Ms
Applications ICC/IF, WB
Clonality Monoclonal
Clone 5A5
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant (partial), N-terminal 2/3 sequence of PARP
Isotype control SM10B (for use in human samples)
Application immunofluorescence, Western Blot
Background PARP (Poly (ADP-ribose) polymerase) is a 113 kD nuclear protein that can exist as a homo- or hetero-dimer. This protein acts as a molecular "nick sensor" and functions in base excision repair, poly(ADP-ribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2 and is a target for caspase cleavage during apoptosis. PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with PARP2, and interacts with PARP3. The 5A5 monoclonal antibody recognizes the N-terminal region of human and mouse PARP and has been shown to be useful for Western blotting and immunofluorescence staining.
General Readings
  1. Cherney, B., et al., 1987. PNAS 84:8370. 2. Ikejima, M., et al., 1990. J. Biol. Chem. 265:21907. 3. Ying, W., et al., 2001. PNAS 98:12227. 4. Noel, G., et al., 2003. BMC Cell Biol. 4:7.
Storage Store at 4C. Do not freeze. Do not freeze.
Immunogen affinity purified
Buffer System:
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Fin
Immunogen affinity purified
Mouse, Human.

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