GTX47529 Patched / PTCH antibody

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0.1 mg / €310.00

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Rabbit anti Human, Mouse, Rat Patched / PTCH


Product Description for Patched / PTCH

Rabbit anti Human, Mouse, Rat Patched / PTCH.
Presentation: Aff - Purified
Product is tested for Paraffin Sections.

Properties for Patched / PTCH

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic peptide (Mouse) -from N-terminal of mouse patched.
Application IHC-P
Background PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.
Concentration 0.2 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Affinity purified with antigen.
Buffer System:
10mM Phosphate buffered saline pH 7.4 containing BSA and 0.1% sodium azide
Affinity purified with antigen.
Aff - Purified
Reacts with Human, Mouse and Rat. Not yet tested in other species.

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