GTX23998 PC2 antibody

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0.1 mg / €310.00

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Goat anti Human PC2


Product Description for PC2

Goat anti Human PC2.
Presentation: Ig Fraction

Properties for PC2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Ig Fraction
Reactivity Hu
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic peptide: NCLTVTFKEYVTV, corresponding to amino acids 539-551 of Human PC 2.
Background 'Polycomb' (Pc) and other members of the Drosophila Polycomb group gene family are part of a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. Pc shares a homologous domain known as the chromodomain with the Drosophila heterochromatin-binding protein, HP1. To isolate human Pc homologs, Satijn et al. (1997) screened a fetal brain cDNA library with a probe containing the nonchromodomain portion of a Xenopus Pc homolog (XPc). They recovered a cDNA encoding a predicted 558-amino acid protein that they designated human Pc2. Human Pc2 and XPc share 48% protein sequence identity. Northern blot analysis revealed that human Pc2 is expressed as a 2.8-kb transcript in all tissues tested with almost equal abundance. Using immunofluorescence, Satijn et al. (1997) found that human Pc2 colocalizes with another human Pc homolog, CBX2 (602770), in interphase nuclei, suggesting that the proteins are part of a complex.
Concentration 0.5 mg/ml
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
IgG fraction
Buffer System:
Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
IgG fraction
Ig Fraction
Expected to cross-react with Human due to sequence homology. Not yet tested in other species.

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