NB100-1153 PC2 antibody

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Goat anti Human PC2


Product Description for PC2

Goat anti Human PC2.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PC2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Drosophila Pc class
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide: NCLTVTFKEYVTV, representing the C-Terminus of the human protein (residues 539-551), according to NP_003646.
Background **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application
'Polycomb' (Pc) and other members of the Drosophila Polycomb group gene family are part of a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. Pc shares a homologous domain known as the chromodomain with the Drosophila heterochromatin-binding protein, HP1. To isolate human Pc homologs, Satijn et al. (1997) screened a fetal brain cDNA library with a probe containing the nonchromodomain portion of a Xenopus Pc homolog (XPc). They recovered a cDNA encoding a predicted 558-amino acid protein that they designated human Pc2. Human Pc2 and XPc share 48% protein sequence identity. Northern blot analysis revealed that human Pc2 is expressed as a 2.8-kb transcript in all tissues tested with almost equal abundance. Using immunofluorescence, Satijn et al. (1997) found that human Pc2 colocalizes with another human Pc homolog, CBX2 (602770), in interphase nuclei, suggesting that the proteins are part of a complex.
Concentration 0.5 mg/ml
General Readings Satijn DP et al. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis. Mol Cell Biol 17:6076-86 (1997). PubMed PMID: 9315667
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
Tris saline containing [pH7.3] with 0.5% BSA
Immunogen affinity purified
Aff - Purified
Expected to cross-react with Human due to sequence homology. Not yet tested in other species.

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