NBP1-22793 PCNA antibody

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Mouse anti Human PCNA PC10


Product Description for PCNA

Mouse anti Human PCNA PC10.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for PCNA

Product Category Primary Antibodies
Quantity 6 ml
Synonyms anti-Cyclin antibody, anti-DNA polymerase delta auxiliary protein antibo, anti-HGCN8729 antibody, anti-MGC8367 antibody, anti-Proliferating Cell Nuclear Antigen antibody, anti-polymerase delta accessory protein antibody
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone PC10
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rat PCNA made in the protein A expression vector pR1T2T.
Isotype control AM03096PU-N
Add. information Research Areas: Stem Cell Markers
Application immunohistochemistry, Immunohistochemistry-Paraffin, This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded and acetone fixed cryostat tissue sections. No further titration is required., immunohistochemistry , Immunohistochemistry-Paraffin
Background PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
No Preservative
IgG purified
PCNA is essential for cellular DNA synthesis. This reacts with proliferating cells in a wide range of normal tissues. The significance of PCNA immunoreactivity in tumors is not fully established yet. However, in non-Hodgkin's lymphoma alinear relation be????

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