GTX12225 PDI [1D3]-ER Marker antibody

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0.1 mg / €310.00

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Mouse anti Chicken, Hamster, Human, Monkey, Mouse, Rat, Sheep, Xenopus PDI [1D3]-ER Marker 1D3


Product Description for PDI [1D3]-ER Marker

Mouse anti Chicken, Hamster, Human, Monkey, Mouse, Rat, Sheep, Xenopus PDI [1D3]-ER Marker 1D3.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for PDI [1D3]-ER Marker

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Chk, Hst, Hu, Mky, Ms, Rt, Sh, Xen
Applications ICC/IF, IP, WB
Clonality Monoclonal
Clone 1D3
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Peptide corresponding to amino acids 499-509 of rat protein disulfide isomerase conjugated to KLH.
Application ICC, IP, WB
Background The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Concentration 1.0 mg/ml
Storage Keep as concentrated solution. Store at 4
Protein G affinity purified
Buffer System:
PBS, pH 7.2, containing 50% Glycerol and 0.1mM PMSF
Protein G affinity purified
Human, Mouse, Rat, Xenopus laevis, Cow, Chicken, Dog, Guinea pig, Hamster, Monkey, Pig and Sheep - Not tested in other species

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