GTX22792 PDI [RL90]-ER Marker antibody

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0.1 ml / €400.00

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Mouse anti Hamster, Human, Mouse, Porcine, Rat PDI [RL90]-ER Marker RL90


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  • GTX22792

Product Description for PDI [RL90]-ER Marker

Mouse anti Hamster, Human, Mouse, Porcine, Rat PDI [RL90]-ER Marker RL90.
Presentation: Ascites
Product is tested for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Paraffin Sections, Western blot / Immunoblot.

Properties for PDI [RL90]-ER Marker

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Ascites
Reactivity Hst, Hu, Ms, Por, Rt
Applications F, ICC/IF, IP, P, WB
Clonality Monoclonal
Clone RL90
Host Mouse
Isotype IgG2a
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Full length native protein (purified) (Rat).
Application IF, IHC-Fr, IHC-P, IP, WB
Background The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol: protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Concentration ascites
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Buffer System:
PBS with 0.05% sodium azide
Cross-reacts with Human, Rat, Mouse and Hamster. Not yet tested in other species.

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