GTX72336 Pds1 (DCS-280) antibody

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0.5 ml / €370.00

Quick Overview

Mouse anti Human Pds1 (DCS-280) DCS-280


Product Description for Pds1 (DCS-280)

Mouse anti Human Pds1 (DCS-280) DCS-280.
Product is tested for Western blot / Immunoblot.

Properties for Pds1 (DCS-280)

Product Category Primary Antibodies
Quantity 0.5 ml
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone DCS-280
Host Mouse
Isotype IgG2a
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Human recombinant full length Pds1 protein
Application WB
Background Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.
Concentration 0.2 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Buffer System:
200ug/ml of antibody purified from ascites fluid by Protein A chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. Also available without BSA and azide at 1mg/ml.
Human. Others not tested.

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