AP10264PU-N PGCC (C-term) antibody

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Rabbit anti Human, Mouse, Rat PGCC


Product Description for PGCC

Rabbit anti Human, Mouse, Rat PGCC.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PGCC

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms PGC-C, Particulate Guanylyl Cyclase C
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic C-terminal peptide for particulate guanylyl cyclase C
Property C-term
Application Western blot: > 1:500.
Background Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, the intracellular levels of cGMP ate maintained by the activity of opposing enzymes: synthesizing gualylyl cyclases (GC) and hydrolyzing phosphodiesterases (PDEs). The synthesizing enzymes (GCs) are found in two forms: cytosolic (soluble) and membrane-bound (particulate), while they share similar structural characteristics, they differ in their mechanisms of physiological regulations. Most importantly, sGC contains a heme group and binds NO that activates the enzyme, while particulate GC is stimulated by natriuretic peptides. Plasma membrane forms of guanylyl cyclase have been shown to function as natriuretic peptide receptors. In response to G-protein couples receptor stimulation, the cGMP can be produced from GTP by either cytoplasmic, soluble guanylate cyclase (sGC) are heterodimers (a & b polypeptide chains), that are stimulated by nitric oxide and carbon monoxide or by particulate membrane-bound guanylyl cyclases which are activated by a complex mechanism by natriuretic peptides. Particulate GC (PGCs) have 7 different isoforms, PGC-A through PGC-G and are expressed in most tissues in isoform specific manner (See Table 1). There is significant structural homology among various PGCs, there is a large N-terminal extracellular domain (ECD), a single TMD and a large intracellular domain with protein kinase activity (KLD), a C-terminal catalytic domain (CD) and in between is a dimmerization domain (DD). The particulate GC-D, also known as olfactory gunylate cyclas, is specifically expressed in a subpopulation of olfactory sensory neurons. The expression of GC-D RNA is restricted to a small, randomly dispersed population of neurons that is within a single topographic zone in the olfactory neuroepithelium and resembles the pattern of the more diverse seven-transmembrane-domain odorant receptors (1). Particulate GC-D resembles two other GC expressed in retina (P-GC-E and F), but diverges considerable form other GCs. These observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.
Concentration 0.75 - 1.2 mg/ml (lot specific)
General Readings
  1. Wedel B. J and Garbers D. L., Trend Endocrinol. Met. 9, 213-219; 1998
  2. Hidaka Y, Matsumoto Y, Shimonishi Y. FEBS Lett 2002 526; 58-62
  3. Deguch T., Amano E., Nakeane M. J. Neurochem. 27, 1027-1034, 1976.
  4. Teunissen C et. al,. Brain Res. 891, 206-212; 2001.
Storage Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity chromatography
Buffer System:
Stabilization buffer
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
This antibody detects PGCC at C-term.

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