discontinued

GTX22865 Phospholamban [2D12] antibody

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0.1 ml / €430.00

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Mouse anti Human, Mouse, Rat, Sheep Phospholamban [2D12] 2D12

GTX22865

Product Description for Phospholamban [2D12]

Mouse anti Human, Mouse, Rat, Sheep Phospholamban [2D12] 2D12.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Phospholamban [2D12]

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Purified
Reactivity Hu, Ms, Rt, Sh
Applications ICC/IF, IP, WB
Clonality Monoclonal
Clone 2D12
Host Mouse
Isotype IgG2a
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5R352
Immunogen:
Synthetic peptide: D(2)KVQYLTRSAIRRASTIEMPQQAR(25). Immunizing peptide corresponds to amino acid residues 2-25 of canine PLB.
GeneID:
5350
Isotype control AM03096PU-N
Application IF, IP, WB
Background Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1-25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25-52) is mostly hydrophobic, protease resistant and stabilizes the pentamer. Following adrenergic stimulation of cardiac muscle, PLB is phosphorylated at Ser16 and at Thr17 which is correlated with stimulation of calcium transport activity across the SR membrane and relaxation of cardiac fibers.
Concentration 1 mg/ml
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Format
Purification:
Protein A purified
Buffer System:
MOPS/PBS with glycine (pH 7.2) and 0.05% sodium azide
Purity:
Protein A purified
State:
Liquid
Purified
Specificity
Specificity:
Cross-reacts with Human, Rat, Mouse, Dog, Pig, Sheep and Guinea pig. Not yet tested in other species.
Gene ID 5350

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