NB120-3132 PI 3 Kinase antibody

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Mouse anti Human, Mouse, Rat PI 3 Kinase 8-2D-4D


Product Description for PI 3 Kinase

Mouse anti Human, Mouse, Rat PI 3 Kinase 8-2D-4D.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for PI 3 Kinase

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, WB
Clonality Monoclonal
Clone 8-2D-4D
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Purified fragment (aa 333 - 430) of recombinant human PI-3-K p85 alpha subunit.
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Background The enzyme PI-3-K phosphorylates at the D-3 position of the inositol ring of PI, PI-4- phosphate and PI-4,5-biphosphate (PI-4,5-P2) to produce their respective PI3-phosphorylated derivatives. PI-3-K exists as a heterodimer of 85 kDa (p85) and 110 kDa (p110) subunits. The p85 subunit contains two SH2 domains and an SH3 domain. It has been shown to associate with and serve as a substrate for activated growth factor receptor tyrosine kinases. p85 may serve as regulator of the catalytic subunit, p110, by acting as the link between PI-3-K and the ligand-activated receptor. Two distinct forms of the p85 subunit are described: p85 alpha, which binds tightly to the catalytic subunit and p85 beta, a protein of unknown function. Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.
General Readings General / background references:Ward SG et al. PI 3-kinase: a pivotal pathway in T-cell activation? Immunol Today 17:187-97 (1996). PubMed PMID: 8871351
Weber G et al. Current issues in the regulation of signal transduction. Adv Enzyme Regul 36:33-55 (1996). PubMed PMID: 8869739
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein G purified
Cross-reacts with Human, Rat and Mouse.Not yet tested in other species.

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