AP14955PU-N PI4KCB (C-term) antibody

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Rabbit anti Human PI4KCB

Product Description for PI4KCB

Rabbit anti Human PI4KCB.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for PI4KCB

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms "phosphatidylinositol 4-kinase, PI4KB", beta polypeptide, catalytic
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PI4KCB.
Property C-term
Application ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Background Phosphoinositides are pivotal precursors to important second messengers and as signaling and molecules. Phosphatidylinositol 4-kinases (PI4Ks) are are crucial regulators of the phosphoinsitide cascade. PI4KCB is a wortmannin-sensitive PI 4-kinase responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. The cellular reservoir of PI4KCB is predominantly cytosolic, however the protein is is activated strongly by recruitment to the membrane to stimulate phosphatidylinositol 4,5-bisphosphate synthesis at the plasma membrane. PI4KCB contains an N-terminal lipid kinase unique domain, which is shared by members of both the PI3 kinase and PI4 kinase families, and a C-terminal catalytic domain, which defines this protein as a member of a much larger protein/lipid kinase family.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration 0.25 mg/ml
General Readings
  1. Wei, Y.J., et al., J. Biol. Chem. 277(48):46586-46593 (2002).
  2. Balla, A., et al., J. Biol. Chem. 277(22):20041-20050 (2002).
  3. Sorensen, S.D., et al., Mol. Pharmacol. 53(5):827-836 (1998).
  4. Saito, T., et al., DNA Res. 4(4):301-305 (1997).
  5. Suzuki, K., et al., DNA Res. 4(4):273-280 (1997).
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
Liquid purified Ig
This antibody reacts to PI4KCB.
Gene ID 5298

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