discontinued

AP14955PU-N PI4KCB (C-term) antibody

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0.1 mg / €335.00

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Rabbit anti Human PI4KCB

Product Description for PI4KCB

Rabbit anti Human PI4KCB.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for PI4KCB

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms "phosphatidylinositol 4-kinase, PI4KB", beta polypeptide, catalytic
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5VWB9
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PI4KCB.
GeneID:
5298
Property C-term
Application ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Background Phosphoinositides are pivotal precursors to important second messengers and as signaling and molecules. Phosphatidylinositol 4-kinases (PI4Ks) are are crucial regulators of the phosphoinsitide cascade. PI4KCB is a wortmannin-sensitive PI 4-kinase responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. The cellular reservoir of PI4KCB is predominantly cytosolic, however the protein is is activated strongly by recruitment to the membrane to stimulate phosphatidylinositol 4,5-bisphosphate synthesis at the plasma membrane. PI4KCB contains an N-terminal lipid kinase unique domain, which is shared by members of both the PI3 kinase and PI4 kinase families, and a C-terminal catalytic domain, which defines this protein as a member of a much larger protein/lipid kinase family.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration 0.25 mg/ml
General Readings
  1. Wei, Y.J., et al., J. Biol. Chem. 277(48):46586-46593 (2002).
  2. Balla, A., et al., J. Biol. Chem. 277(22):20041-20050 (2002).
  3. Sorensen, S.D., et al., Mol. Pharmacol. 53(5):827-836 (1998).
  4. Saito, T., et al., DNA Res. 4(4):301-305 (1997).
  5. Suzuki, K., et al., DNA Res. 4(4):273-280 (1997).
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to PI4KCB.
Species:
Human.
Gene ID 5298

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