NB100-55932 PIKE antibody

See related secondary antibodies

Search for all "PIKE"

Quick Overview

Rabbit anti Human, Mouse PIKE


Product Description for PIKE

Rabbit anti Human, Mouse PIKE.
Product is tested for Western blot / Immunoblot.

Properties for PIKE

Product Category Primary Antibodies
Quantity 0.1 mg
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Human PIKE (CT) (Centaurin gamma 1) peptide.
Background Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity (1). PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis.
Storage Store at 4C. Do not freeze.
Buffer System:
PBS containing 0.02% sodium azide.
Human, Mouse Not yet tested in other species.

Accessory Products

  • LinkedIn