NB120-5782 PKC beta 1 antibody

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Rabbit anti Human PKC beta 1


Product Description for PKC beta 1

Rabbit anti Human PKC beta 1.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PKC beta 1

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic phosphopeptide derived from a region of human PKC beta 1 that contains threonine 642.
Background Protein Kinase C beta 1 (PKC beta 1) is an 80 kDa member of the conventional group (cPKCs: sensitive to diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, transcriptional regulation and tumor promotion. PKC beta 1 is phosphorylated on three sites, threonine 500 in the activation loop, threonine 642 in the turn loop and serine 661 in the hydrophobic loop. Autophosphorylation of PKC beta 1 on threonine 642 is crucial for its activation and catalytic activity. Threonine 642 mediates PKC beta 1 ability to activate c-Fos in response to phorbol esters.
General Readings General / background references:Gao T & Newton AC The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem 277:31585-92 (2002). PubMed PMID: 12080070
Edwards AS et al. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J Biol Chem 274:6461-8 (1999). PubMed PMID: 10037738
Keranen LM et al. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5:1394-1403 (1995). PubMed PMID: 8749392
Newton AC Protein kinase C: structure, function, and regulation. J Biol Chem 270:28495-8 (1995). PubMed PMID: 7499357
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: 50% Glycerol, PBS, 1mg/ml BSA. pH 7.3
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human.Expected to cross-react with Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species.

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