NB120-5797 PKC gamma antibody

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0.05 ml / €380.00

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Rabbit anti Human PKC gamma


Product Description for PKC gamma

Rabbit anti Human PKC gamma.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PKC gamma

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic phosphopeptide derived from a region of human PKC gamma that contains threonine 674.
Background Protein Kinase C gamma (PKC gamma) is an 80 kDa member of the conventional grou(cPKCs: sensitive to calcium, diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC gamma plays a key role in neuronal signal transduction and in regulating intercellular communication. The activation loop threonine (threonine 514 in PKC gamma) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1), which is necessary for its autophosphorylation on threonine 655 in the turn loop, and threonine 674 in the hydrophobic loop of the carboxy terminus, a critical step in generating a catalytically mature enzyme. The phosphorylation of the hydrophobic loop in the carboxyl terminus of PKCs is believed to be a key determinant in regulating PKC interaction with PDK1.
Concentration 0.5 mg/ml
General Readings General / background references:Nguyen TA et al. LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells. Exp Eye Res 76:565-72 (2003). PubMed PMID: 12697420
Aronowski J et al. Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia. J Cereb Blood Flow Metab 20:343-9 (2000). PubMed PMID: 10698072
Dutil EM et al. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol 8:1366-75 (1998). PubMed PMID: 9889098
Toker A Signaling through protein kinase C. Front Biosci 3:D1134-47 (1998). PubMed PMID: 9792904
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA. pH 7.3
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen) and Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species.

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