AM33283PU-N Plasma Cell antibody

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0.2 mg / €390.00
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Quick Overview

Mouse anti Human Plasma Cell SPM310

Product Description for Plasma Cell

Mouse anti Human Plasma Cell SPM310.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Plasma Cell

Product Category Primary Antibodies
Quantity 0.2 mg
Synonyms Plasma B cell, Plasmocytes
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone SPM310
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Pancreatic cancer related Mucin.
Isotype control AM03096PU-N
Application Immunohistochemistry on Paraffin Sections: Use Plasma Cell antibody at 0.5-1 µg/ml for 30 minutes at RT. 
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
Positive ControlTonsil or Lymph node. 
Note that this Monoclonal Antibody is not suitable for staining Frozen tissues.
Background Plasma cells (also called plasma B cells or plasmocytes), which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement.
Concentration 0.2 mg/ml
General Readings
  1. Turley H, Jones M, Erber W, Mayne K, de Waele M, Gatter K. VS38: a new monoclonal antibody for detecting plasma cell differentiation in routine sections. J Clin Pathol. 1994 May;47(5):418-22. PubMed PMID: 7517959. (Free PMC Article available)
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Protein A/G Chromatography
Buffer System:
10mM PBS
Preservatives:
0.05% Sodium Azide
Stabilizers:
0.05% BSA
State:
Liquid purified IgG fraction from Bioreactor Concentrate
Purified
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody recognizes an intracytoplasmic antigen which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells.
Plasma cells, which are large lymphocytes derived from an antigen- specific B cell, secrete antibodies and are responsible for humoral immunity. P lasma cells differentiate from B cells upon stimulation by CD4 + lymphocytes. The B cell acts as an antigen-presenting cel l (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contai n basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteri stic cartwheel arrangement. This Plasma Cell Marker antibody superbly recognizes normal and neoplastic plasma cell s in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential val ue in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho- plasmacytoid lymphoma from lymphocytic and follicular lymp homa.
Cellular Localization: Cytoplasmic. 
Negative Species: Rat.

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