NB120-3290 Plastin L antibody

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Mouse anti Human Plastin L LPL4A.1


Product Description for Plastin L

Mouse anti Human Plastin L LPL4A.1.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Plastin L

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications ICC/IF, IP, WB
Clonality Monoclonal
Clone LPL4A.1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Isotype control AM03095PU-N, SM10P (for use in human samples)
Background L plastin is a leukocyte specific actin bundling protein from the fimbrin family of proteins. It has two actin binding domains and two EF hand type calcium binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L plastin may play a role in regulating integrin mediated adhesion in leukocytes. L plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterone in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
General Readings This product has been used in:Lollike K et al. Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. J Biol Chem 276:17762-9 (2001). PubMed PMID: 11279160
General / background references:Jones SL & Brown EJ FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. J Biol Chem 271:14623-30 (1996). PubMed PMID: 8663066
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein G purified
Cross-reacts with Human.Does not cross-react with Mouse.Not yet tested in other species.

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