DM402-05 PML antibody

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Mouse anti Human PML PG-M3


Product Description for PML

Mouse anti Human PML PG-M3.
Presentation: Supernatant
Product is tested for Frozen Sections, Paraffin Sections.

Properties for PML

Product Category Primary Antibodies
Quantity 0.5 ml
Synonyms PML Protein
Presentation Supernatant
Reactivity Hu
Applications C, P
Clonality Monoclonal
Clone PG-M3
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

BALB/C mice were immunized with a synthetic peptide corresponding to amino acids 37 to 51 of PML protein.
Application Immunohistochemistry on frozen and paraffin embedded sections:
diluted of 1:10 to 1:50 in an ABC method (30 min at room temperature)
Recommended Positive control: Hodgkin's lymphoma.
Background PML is frequently overexpressed in Hodgkin's and Reed-Sternberg cells of Hodgkin's disease. It is also overexpressed in carcinomas of larynx and thyroid (papillary), epithelial thymomas and Kaposi's sarcoma. Acute promyelocytic leukemia, which is characterized by fusion of promyelocytic leukemia (PML) and Retinoic Acid Receptor alpha genes by a reciprocal 15:17 chromosomal translocation. The fusion protein thus produced blocks the terminal differentiation of hematopoietic cells and apoptosis.
General Readings
  1. Borrow et al. Science 249: 1577, 1990.
  2. Dyck et al. Blood 82: 862, 1994.
  3. Grignani et al. Cell 74: 423, 1993.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
10 mM citrate buffer, pH 6.0 - containing sodium azide as preservative.
Liquid tissue culture supernatant
This antibody reacts with a peptide located in the aminoterminal region of the human PML protein.

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