AM26200PU-N PMP22 (N-term) antibody

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0.1 mg / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human, Rhesus Monkey PMP22 CF1

AM26200PU-N

Product Description for PMP22

Mouse anti Human, Rhesus Monkey PMP22 CF1.
Properties: (N-term)
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections, Enzyme Immunoassay.

Properties for PMP22

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms GAS-3, GAS3, Growth arrest-specific protein 3, PMP-22, Peripheral myelin protein 22
Presentation Purified
Reactivity Hu, Rhesus Mky
Applications E, P, WB
Clonality Monoclonal
Clone CF1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q01453
Immunogen:
Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue
AA Sequence:
CRHPEWHLNSDYSYG
GeneID:
5376
Property N-term
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Immunoassay.
Western blot: The typical starting working dilution is 1:50.
Immunohistochemistry on paraffin sections.
Background PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy.
Concentration 0.1 mg/ml
General Readings
  1. Gregson NA, Zhang G, Pritchard J, Wang A, Sanvito L, Hayday AC, et al. Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system. J Peripher Nerv Syst. 2007 Mar;12(1):2-10. PubMed PMID: 17374097.
Storage

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Format
Purification:
Protein G
Buffer System:
PBS
Preservatives:
0.02% sodium azide
Stabilizers:
0.1% bovine serum albumin
State:
Liquid 0.2 µm filtered Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, rhesus monkey
Specificity
Specificity:
This antibody recognizes human peripheral myelin protein 22 (PMP22).
Gene ID 5376

Accessory Products

Proteins and/or Positive Controls

Proteins for PMP22 (6 products)

Catalog No. Species Pres. Purity   Source  

PMP22 (transcript variant 1)

PMP22 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PMP22 (transcript variant 3)

PMP22 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PMP22

PMP22 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

PMP22

PMP22 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

PMP22

PMP22 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

PMP22

PMP22 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
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