NB100-74506 PPAR alpha [Ser12] Phosphospecific antibody

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0.1 mg / €360.00

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Rabbit anti Mouse PPAR alpha [Ser12] Phosphospecific


Product Description for PPAR alpha [Ser12] Phosphospecific

Rabbit anti Mouse PPAR alpha [Ser12] Phosphospecific.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PPAR alpha [Ser12] Phosphospecific

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic phosphopeptide corresponding to residues I(a.a. 8) C P L (pS) P L E A D D L(a.a. 19) of mouse PPAR alpha.
Application Western Blot 2 ug/ml
Background Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase & cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex.

The corresponding gene for the phospho-PPAR alpha is NR1C1.
Storage Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Immunogen affinity purified
Aff - Purified
This antibody is reactive against Mouse.

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