AP07622PU-N PPP1R13L antibody

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50 µg / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human PPP1R13L

Product Description for PPP1R13L

Rabbit anti Human PPP1R13L.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for PPP1R13L

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms IASPP, Inhibitor of ASPP protein, NFkB-interacting protein 1, NKIP1, PPP1R13B-like protein, PPP1R13BL, RAI, RelA-associated inhibitor
Presentation Aff - Purified
Reactivity Hu
Applications E, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8WUF5
Immunogen:
Synthetic peptide corresponding to Amino Acids 780-797 of human iASPP (isoform 1) protein.
GeneID:
10848
Application ELISA: 1/40000 - 1/160000.
Immunofluorescence.
Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 1/1000 - 1/5000.
Background ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.
Concentration 1 mg/ml
Storage Store the antibody undiluted (in aliquots) at -20°C.
Dilute only prior to immediate use.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography.
Buffer System:
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preservative.
State:
Liquid purified IgG fraction.
Aff - Purified
Specificity
Species:
Human, Bovine, Dog and Mouse.
Gene ID 10848

Accessory Products

Proteins and/or Positive Controls

Proteins for PPP1R13L (4 products)

Catalog No. Species Pres. Purity   Source  

PPP1R13L

PPP1R13L Human Purified
  Abnova Taiwan Corp.

PPP1R13L

PPP1R13L Human Purified
  Abnova Taiwan Corp.

PPP1R13L

PPP1R13L Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

PPP1R13L

PPP1R13L Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for PPP1R13L (1 products)

Catalog No. Species Pres. Purity   Source  

PPP1R13L 293T Cell Transient Overexpression Lysate(Denatured)

PPP1R13L 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.
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