R-086-50 proBDNF antibody

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Rabbit anti Human, Mouse, Rat proBDNF


Product Description for proBDNF

Rabbit anti Human, Mouse, Rat proBDNF.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for proBDNF

Product Category Primary Antibodies
Quantity 0.05 mg
Synonyms Precursor
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide (C-ELLDEDQKVRPNEE) as a part of human BDNF precursor protein (aa: 69-82) conjugated to KLH
Background BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer?s, and Parkinson?s disease. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post Translation Modification (PTM): The propeptide is N-glycosylated and glycosulfated. PTM: Converted into mature BDNF by plasmin (PLG) (By similarity). DISEASE: Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. SIMILARITY: Belongs to the NGF-beta family.
General Readings
  1. A Acheson et al (1995) Nat. 74: 450-3 ; 2. Q Yan et al (1994) J. Neurosci. 14(9): 5281-91 ; 3. XF Zhou et al (1996) Neurosci. 74: 945-53 ; 4. XF Zhou, et al (1998) Exp. Neurol. 149: 237-42 ; 5. B Mellstrom et al (2004) Crit Rev Neurobiol 16, 43-9 ; 6. I Tapia-Arancibia et al (2004) Front Neuroendocrinol 25, 77-107 ; 7. S Pezet, et al (2002) Brain Res Brain Res Rev 40, 240-9 ; 8. Barde Y. A. et al (1989) EMBO J. 1: 549 ; 9. Conner J et al. (1997) J. Neurosci. 17: 2295
Affinity purified
Buffer System:
Reconstitute in 50 ul of sterile water. Centrifuge to remove any insoluble material.
Affinity purified
Aff - Purified
This antiserum is known to react with human, mouse and rat proBDNF and also expected to recognise other mammalian proBDNF.

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