AM11188PU-S Progesterone receptor (412-526) antibody

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Regular Price: 0.1 ml / €250.00

Special Price: 0.1 ml / €175.00

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Quick Overview

Rabbit anti Human Progesterone receptor SP2

Product Description for Progesterone receptor

Rabbit anti Human Progesterone receptor SP2.
Properties: (412-526)
Presentation: Supernatant
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Progesterone receptor

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR
Presentation Supernatant
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone SP2
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06401
Immunogen:
Recombinant protein encoding Human Progesterone receptor aa 412-526.
GeneID:
5241
Remarks:
Epitope: aa 412-526.
Molecular Weight: 116kDa.
Property 412-526
Application Western Blot: Use at 1/50 for 1 hour at RT.
Immunohistochemistry on Paraffin Sections: 1/400 for 30 min at RT.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween.
Positive Control: Breast carcinoma.
Background The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
General Readings
  1. Rocha R, Nunes C, Rocha G, Oliveira F, Sanches F, Gobbi H. Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry. Pathol Res Pract. 2008;204(9):655-62. doi: 10.1016/j.prp.2008.03.010. Epub 2008 Jun 18. PubMed PMID: 18565685.
  2. Huang Z, Zhu W, Meng Y, Xia H. Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): no heat pretreatment but effective for paraffin section immunohistochemistry. Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):229-33. PubMed PMID: 16785796.
  3. Cano G, Milanezi F, Leitão D, Ricardo S, Brito MJ, Schmitt FC. Estimation of hormone receptor status in fine-needle aspirates and paraffin-embedded sections from breast cancer using the novel rabbit monoclonal antibodies SP1 and SP2. Diagn Cytopathol. 2003 Oct;29(4):207-11. PubMed PMID: 14506673.
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
State:
Liquid Tissue Culture Supernatant with 0.09% Sodium Azide as preservative.
Supernatant
Species Reactivity
Species reactivity (tested):
Human.
Specificity
Specificity:
This monoclonal anti-Human Progesterone Receptor antibody (Clone SP2) reacts with progesterone receptor forms alpha and beta. It stains nuclei in breast, ovarian and endometrial epithelia, as well as myometrial nuclei.
The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway.
Cellular Localization: Nucleus.
Gene ID 250
FocusOn and Reviews
FocusOns:

Accessory Products

Proteins and/or Positive Controls

Proteins for Progesterone receptor (7 products)

Catalog No. Species Pres. Purity   Source  

Progesterone receptor

Progesterone receptor Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Progesterone receptor

Progesterone receptor Human Purified E. coli
  Acris Antibodies GmbH

Progesterone receptor

Progesterone receptor Human Purified E. coli
  Acris Antibodies GmbH

Progesterone receptor

Progesterone receptor Human Purified E. coli
  Acris Antibodies GmbH

Progesterone receptor

Progesterone receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Progesterone receptor

Progesterone receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Progesterone receptor

Progesterone receptor Human
  Abnova Taiwan Corp.

Positive controls for Progesterone receptor (1 products)

Catalog No. Species Pres. Purity   Source  

PGR overexpression lysate

PGR overexpression lysate
0.1 mg / €480.00
  OriGene Technologies, Inc.
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