discontinued

GTX23321 Proteasome 19S S6' antibody

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Search for all "Proteasome 19S S6'"

0.1 ml / €440.00

Quick Overview

Rabbit anti Human Proteasome 19S S6'

GTX23321

Product Description for Proteasome 19S S6'

Rabbit anti Human Proteasome 19S S6'.
Presentation: Ig Fraction
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Proteasome 19S S6'

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Ig Fraction
Reactivity Hu
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant full length protein (Human).
Application IP, WB
Background Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
Storage Keep as concentrated solution. Store at 4
Format
Purification:
IgG fraction
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Purity:
IgG fraction
State:
Liquid
Ig Fraction
Specificity
Specificity:
Human - Not yet tested in other species

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