GTX23331 Proteasome 20S Y antibody

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0.1 mg / €380.00

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Rabbit anti Bovine, Human, Mouse Proteasome 20S Y


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  • GTX23331
  • GTX23331
  • GTX23331

Product Description for Proteasome 20S Y

Rabbit anti Bovine, Human, Mouse Proteasome 20S Y.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Proteasome 20S Y

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Bov, Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic Peptides: C(41)RSGSAADTQAV/IADAVTY(58).Immunizing peptides correspond to amino acid residues 41-58 from human proteasome 20S Y and amino acid residues 74-91 from frog. These sequences are completely conserved in mouse, rat, and zebrafish.
Application WB
Background Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).
Concentration 1 mg/ml
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human, Mouse (see review) and Cow. Expected to cross-react with Rat, Xenopus laevis and Zebrafish due to sequence homology. Not yet tested in other species.

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