discontinued

GTX23332 Proteasome 20S Z antibody

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0.1 mg / €440.00

Quick Overview

Rabbit anti Human Proteasome 20S Z

GTX23332

Product Description for Proteasome 20S Z

Rabbit anti Human Proteasome 20S Z.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Proteasome 20S Z

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic Peptide: CE(263)IEVLEETVQTMDTS(NH2)(277). Immunizing peptides correspond to amino acid residues 263-277 from human proteasome 20S Z protein. This sequence is completely conserved in mouse and 97% conserved in rat protein.
Application WB
Background Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Purity:
Immunogen affinity purified
State:
Liquid
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human and Cow. Not yet tested in other species.

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