GTX23333 Proteasome Activator 11S REG alpha antibody

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0.1 mg / €440.00

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Rabbit anti Hamster, Human, Mouse, Rat Proteasome Activator 11S REG alpha


Product Description for Proteasome Activator 11S REG alpha

Rabbit anti Hamster, Human, Mouse, Rat Proteasome Activator 11S REG alpha.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Proteasome Activator 11S REG alpha

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hst, Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Peptide sequence: R(5)VQPEAQAKVDVFREDLC(22). Immunizing peptide corresponds to amino acid residues 5-22 of human proteasome activator 11S REG alpha. This sequence differs from the mouse and rat 11S REG alpha protein by a single amino acid residue.
Application WB
Background Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
Concentration 2.1 mg/ml
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human, Rat, Mouse, Dog and Hamster. Not yet tested in other species.

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