AM26362PU-N Protein C (activated) (light chain) antibody

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0.1 mg / €430.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rat anti Human Protein C PC107


Product Description for Protein C

Rat anti Human Protein C PC107.
Properties: (activated) (light chain)
Presentation: Purified
Product is tested for Western blot / Immunoblot, Enzyme Immunoassay.

Properties for Protein C

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms APC
Presentation Purified
Reactivity Hu
Applications E, WB
Clonality Monoclonal
Clone PC107
Host Rat
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Property activated, light chain
Application Immunoassays.
Western blot:
The typical starting working dilution is 1:50.
Background Protein C (PC) is an important regulator of the blood coagulation system. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM)-thrombin complex on the phospholipid surface of endothelial cells, monocytes, and platelets. This process is enhanced in the presence of the endothelial protein C receptor (EPCR). In addition to its regulatory function in the blood coagulation system, studies indicate important roles for APC in inflammatory processes. The administration of APC prevents lethal effects of Escherichia coli-associated sepsis in experimental animal models and appears effective for the treatment of patients with meningococcemia or acquired PC deficiency. Treatment with APC improves the clinical outcome of patients with sepsis. The anti-inflammatory activity of APC depends on its ability to suppress the secretion of cytokines as tumor necrosis factor-alpha by inflammatory cells, the activation and extravasation of leukocytes and the expression and function of adhesion molecules. APC may also suppress the expression of growth factors and members of nuclear factor-kB (NF-kB) family of transcription factors.
Concentration 0.1 mg/ml

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Protein G
Buffer System:
0.02% sodium azide
0.1% bovine serum albumin
Liquid 0.2 µm filtered Ig fraction
Species Reactivity
Species reactivity (tested):
Monoclonal antibody PC107 is specific for activated Protein C (APC). It it lacks reactivity for Protein C. The antibody recognizes the light chain of the APC molecule.

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