MSP01 Pyruvate Dehydrogenase Complex (PDH) Immunocapture antibody

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Mouse anti Bovine, Human Pyruvate Dehydrogenase Complex (PDH) Immunocapture 15D3G9C11

Product Description for Pyruvate Dehydrogenase Complex (PDH) Immunocapture

Mouse anti Bovine, Human Pyruvate Dehydrogenase Complex (PDH) Immunocapture 15D3G9C11.
Presentation: Agarose
Product is tested for Immunoprecipitation.

Properties for Pyruvate Dehydrogenase Complex (PDH) Immunocapture

Product Category Primary Antibodies
Quantity 0.25 mg
Synonyms PDH Immunocapture
Presentation Agarose
Reactivity Bov, Hu
Applications IP
Clonality Monoclonal
Clone 15D3G9C11
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer MitoSciences Inc.

Datasheet Extract

Porcine Heart PDH.
Application Immunoprecipitation: 100 µg mAb can capture at least 5 µg PDH complex from 1 mg solubilized bovine heart mitochondria.
Not recommended for Western blotting or Immunohistochemistry.
Background The pyruvate dehydrogenase complex (PDH) is at the center of aerobic carbohydrate metabolism. It is localized in the matrix space of mitochondria where it catalyzes the irreversible oxidative decarboxylation of pyruvate entering the organelle to produce acetyl-CoA, NADH and CO2. PDH is a complex of three different enzymes that channel substrate and product. These are pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2) and dihydrolipoamide dehydrogenase (E3). PDH deficiencies, diabetes, starvation, sepsis, and possibly Alzheimer's disease have been linked to altered PDH functioning.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Biochemical Fractionation.
Buffer System:
HEPES-Buffered Saline (HBS) with 0.02% Sodium Azide as a preservative.
Liquid purified IgG fraction.
Species Reactivity
Species reactivity (tested):
Human and Bovine.
This antibody is irreversibly crosslinked to protein G-agarose beads which can immunocapture ~13 µg of PDH complex from heart mitochondria.

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