NB100-64723 Reticulum Cells antibody

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Mouse anti Rat Reticulum Cells ED11


Product Description for Reticulum Cells

Mouse anti Rat Reticulum Cells ED11.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Enzyme Immunoassay.

Properties for Reticulum Cells

Product Category Primary Antibodies
Quantity 0.125 mg
Presentation Aff - Purified
Reactivity Rt
Applications C, E
Clonality Monoclonal
Clone ED11
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rat spleen cell homogenate
Application ELISA, Immunohistochemistry-Frozen, Immunohistochemistry-Frozen and ELISA, ELISA , Immunohistochemistry-Frozen 1:100 - 1:300
Background Dendritic cells (DCs) are known as the professional antigen presenting cells. DCs perform the important role of capturing and processing antigen and presenting it to naïve T-helper cells to initiate the immune response. Distinct subsets of DCs have been described, they include interdigitating reticulum cells. The antigen recognized is found on a subpopulation (approximately 5%) of circulating monocytes and peritoneal macrophages, as well as on in vitro LPS and IFN stimulated macrophages and on all macrophages after 3 weeks in culture. It is absent from all other blood cells. Detects a subpopulation of reticulum cells in T-cell areas of lymph nodes and spleen and their in vitro correlates. It is also useful for the detection of a macrophage subpopulation in the thymus. A minor but distinct population of leukocytes in the kidney cortex is also positively stained by this antibody. The antigen is absent in the skin.
Concentration 0.5 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
IgG purified
Buffer System:
0.09% Sodium Azide
IgG purified
Aff - Purified
NB100-64723 recognizes reticular elements in the T cell areas and B cell follicles of spleen, lymph nodes, Peyers patches, bronchus and gut associated lymphoid tissues (BALT and GALT). In the thymus a reticular pattern is observed throughout the cortex capsule, the medulla is negative. In non-lymphoid organs positivity is seen only in reticular elements of the small intestine. No staining of liver, lung, skin, kidney, brain, pancreas or heart is seen. Biochemical analysis has revealed that ED11 recognizes complement factor C3. in vivo studies have shown that ED11 blocks immune complex trapping on follicular dendritic cells.

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