AP11802PU-N Rsd-2 (N-term) antibody

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Rabbit anti C. elegans Rsd-2


Product Description for Rsd-2

Rabbit anti C. elegans Rsd-2.
Properties: (N-term)
Presentation: Purified

Properties for Rsd-2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Hypothetical protein rsd-2, rsd-2
Presentation Purified
Reactivity Ce
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of C. elegans Rsd-2.
Property N-term
Add. information Molecular weight: 142169 Da
Application ELISA 1:1,000.
Background In C. elegans, local introduction of double-stranded RNA initiates silencing of the target gene through the organism. Systemic RNAi effects have not been detected in other species, including mammals. C. elegans mutant proteins that block systemic silencing (termed rsd or RNAi spreading defective proteins)have been identified. These mutants function normally in the uptake of dsRNA from the gut, but are unable to further parcel this dsRNA to the germline, thus blocking organism wide phenotypic changes. While rsd-2 is a large protein displaying no known motifs or homologs that would provide a clue to its specific molecular function, there is evidence that rsd-2 and rsd-6 act in a complex to mediate the systemic RNAi phenomenon.
Concentration 0.25 mg/ml
General Readings
  1. Tijsterman,M et al. Current Biology. 2004. 14:111116.
  2. Kim, JK et al. Science. 2005. 308(5725):1164-7.
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
Liquid Ig fraction
This antibody detects Rsd-2 at N-term.
C. elegans.

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