TA306772 RUNX1 antibody

Rabbit Polyclonal RUNX1 Antibody

See related secondary antibodies

Search for all "RUNX1"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat RUNX1

Product Description for RUNX1

Rabbit anti Human, Mouse, Rat RUNX1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for RUNX1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms 1, AML-1, AML1, AML1-EVI-1, AMLCR1, Acute myeloid leukemia 1 protein, CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer-binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q01196
Immunogen:
RUNX1 antibody was raised against a 16 amino acid peptide from near the center of human RUNX1.
GeneID:
861
Add. information Blocking peptide available: AP30746CP-N
Application ELISA.
Western blot: 1 - 2 μg/ml.
Background RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF.
General Readings
  1. Lund AH, van Lohuizen M. RUNX: a trilogy of cancer genes. Cancer Cell. 2002 Apr;1(3):213-5. PubMed PMID: 12086855.
  2. Inoue K, Shiga T, Ito Y. Runx transcription factors in neuronal development. Neural Dev. 2008 Aug 26;3:20. doi: 10.1186/1749-8104-3-20. PubMed PMID: 18727821. (Free PMC Article available, 1 images available)
  3. North TE, Stacy T, Matheny CJ, Speck NA, de Bruijn MF. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells. 2004;22(2):158-68. PubMed PMID: 14990855.
  4. Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006 Apr 21;125(2):301-13. PubMed PMID: 16630818.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Peptide affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
Specificity
Specificity:
This antibody detects RUNX1.

Accessory Products

Proteins and/or Positive Controls

Proteins for RUNX1 (3 products)

Catalog No. Species Pres. Purity   Source  

RUNX1 (transcript variant 2)

RUNX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

RUNX1

RUNX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

RUNX1

RUNX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

Positive controls for RUNX1 (3 products)

Catalog No. Species Pres. Purity   Source  

RUNX1 Lysate

Western Blot: RUNX1 Lysate [NBL1-15624] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for RUNX1
  Novus Biologicals Inc.

RUNX1 overexpression lysate

RUNX1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.

RUNX1 overexpression lysate

RUNX1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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