discontinued

TA352286 RUNX1 antibody

Mouse Monoclonal anti-RUNX1 Antibody

See related secondary antibodies

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Mouse anti Human, Mouse RUNX1 1C5B16

TA352286

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  • TA352286

Product Description for RUNX1

Mouse anti Human, Mouse RUNX1 1C5B16.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for RUNX1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms 1, AML-1, AML1, AML1-EVI-1, AMLCR1, Acute myeloid leukemia 1 protein, CBF-alpha-2, CBFA2, Core-binding factor subunit alpha-2, EVI-1, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Polyomavirus enhancer-binding protein 2 alpha B subunit, Runt-related transcription factor, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit
Presentation Purified
Reactivity Hu, Ms
Applications ICC/IF, WB
Clonality Monoclonal
Clone 1C5B16
Host Mouse
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q01196
Immunogen:
Partial human RUNX1 recombinant protein (191-350 aa) expressed in E. coli.
GeneID:
861
Application WB
IF
Background RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.
Format
Purification:
The antibody was purified by affinity chromatography.
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for RUNX1 (3 products)

Catalog No. Species Pres. Purity   Source  

RUNX1 (transcript variant 2)

RUNX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

RUNX1

RUNX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

RUNX1

RUNX1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
  Abnova Taiwan Corp.

Positive controls for RUNX1 (3 products)

Catalog No. Species Pres. Purity   Source  

RUNX1 Lysate

Western Blot: RUNX1 Lysate [NBL1-15624] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for RUNX1
  Novus Biologicals Inc.

RUNX1 overexpression lysate

RUNX1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.

RUNX1 overexpression lysate

RUNX1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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