TA306396 SCO2 antibody

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0.1 mg / €325.00
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Rabbit anti Human SCO2

TA306396

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  • TA306396
  • TA306396

Product Description for SCO2

Rabbit anti Human SCO2.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for SCO2

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Synthesis of cytochrome c oxidase 2, cytochrome oxidase deficient homolog 2
Presentation Aff - Purified
Reactivity Hu
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5KW01
Immunogen:
SCO2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human SCO2.
GeneID:
3184203
Add. information Blocking peptide available: AP30767CP-N
Application ELISA.
Western blot: 0.5 – 1 μg/ml.
Immunohistochemistry on paraffin sections.
Background Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.
General Readings
  1. Glerum DM, Shtanko A, Tzagoloff A. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J Biol Chem. 1996 Aug 23;271(34):20531-5. PubMed PMID: 8702795.
  2. Horng YC, Leary SC, Cobine PA, Young FB, George GN, Shoubridge EA, et al. Human Sco1 and Sco2 function as copper-binding proteins. J Biol Chem. 2005 Oct 7;280(40):34113-22. Epub 2005 Aug 9. PubMed PMID: 16091356.
  3. Matoba S, Kang J-G, Patino WD, et al. p53 regulates mitochondrial respiration. Science 2006; 312:1650-3.
  4. Papadopoulou LC, Sue CM, Davidson MM, Tanji K, Nishino I, Sadlock JE, et al. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. Nat Genet. 1999 Nov;23(3):333-7. PubMed PMID: 10545952.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Peptide affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects SCO2.

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