AP06459PU-N SENP5 antibody

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0.1 mg / €350.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat SENP5

AP06459PU-N

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  • AP06459PU-N

Product Description for SENP5

Rabbit anti Human, Mouse, Rat SENP5.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for SENP5

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~80 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q96HI0
GeneID:
205564
Application Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Background SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins, including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.
Concentration 1.0 mg/ml
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate Buffered Saline (PBS), pH~7.2
Preservatives:
15mM Sodium Azide
State:
Liquid purified Ig fraction (>95% pure by SDS-PAGE).
Aff - Purified
Specificity
Specificity:
This antibody detects endogenous levels of SENP5 protein.
(region surrounding Leu681)
Species:
Human, Mouse. and Rat.
Gene ID 205564

Accessory Products

Proteins and/or Positive Controls

Proteins for SENP5 (5 products)

Catalog No. Species Pres. Purity   Source  

SENP5

SENP5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

SENP5

SENP5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

SENP5

SENP5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

SENP5

SENP5 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

SENP5

SENP5 Human
  Abnova Taiwan Corp.

Positive controls for SENP5 (2 products)

Catalog No. Species Pres. Purity   Source  

SENP5 Lysate

Western Blot: SENP5 Lysate [NBL1-15811] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SENP5
  Novus Biologicals Inc.

SENP5 overexpression lysate

SENP5 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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