discontinued

GTX23440 Serotonin N-acetyltransferase phospho S206 antibody

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50 µg / €380.00

Quick Overview

Rabbit anti Mouse, Rat Serotonin N-acetyltransferase

Product Description for Serotonin N-acetyltransferase

Rabbit anti Mouse, Rat Serotonin N-acetyltransferase.
Properties: phospho S206
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for Serotonin N-acetyltransferase

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide: C(198)HTFLRRNS(p)GC(208).Immunizing phosphopeptide corresponds to C-terminal amino acid residues 198-208 of rat AA-NAT. This sequence is completely conserved between rat and mouse AA-NAT protein.
Property phospho S206
Application WB
Background Pineal gland Serotonin N-acetyltransferase (Aryl-alkylamine N-acetyltransferase, AA-NAT) is an ~23 kDa protein which is the rate-limiting enzyme in melatonin synthesis. Melatonin serves as the hormonal signal of the daily light / dark cycle, or body clock. The nocturnal oscillation in enzyme activity ranges by 10- to 100-fold depending on species among vertebrates. Studies have shown that AA-NAT is regulated by cAMP at both the mRNA and protein levels. AA-NAT has putative protein kinase A (PKA) sites at Thr 29 and Ser 206. Phosphorylation of AA-NAT at these residues might play a role in protein inactivation via proteasome-dependent degradation.
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Format
Purification:
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA and 0.05% sodium azide
Purity:
Immunogen affinity purified
State:
Liquid
Aff - Purified
Specificity
Specificity:
Cross-reacts with Rat. Expected to cross-react with Mouse due to sequence homology. Not yet tested in other species.

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