AM26249PU-N Serum Amyloid A protein (SAA) antibody

See related secondary antibodies

Search for all "Serum Amyloid A protein (SAA)"

0.1 mg / €420.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human, Mouse Serum Amyloid A protein (SAA) Reu86.5

AM26249PU-N

Product Description for Serum Amyloid A protein (SAA)

Mouse anti Human, Mouse Serum Amyloid A protein (SAA) Reu86.5.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Enzyme Immunoassay, Paraffin Sections, Frozen Sections.

Properties for Serum Amyloid A protein (SAA)

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms SAA1, SAA2
Presentation Purified
Reactivity Hu, Ms
Applications C, E, P, WB
Clonality Monoclonal
Clone Reu86.5
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P02735
Immunogen:
Human SAA and Helix Pomatia Haemocyanine
GeneID:
6288
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Immunohistochemistry on frozen and paraffin sections: The typical starting working dilution is 1:10.
Immunoassays.
Western blot: The typical starting working dilution is 1:10.
Background

The serum amyloid A (SAA) family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma, and constitutive SAAs (C-SAAs). Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000-fold during inflammation. Several studies have stressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP.
Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumor tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate. Also adhesion motifs were identified and new functions, affecting cell adhesion, migration, proliferation and aggregation discovered. These findings emphasize the importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high-density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease processes. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues.
Elevated levels of SAA over time predispose to secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissue and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis.

Concentration 0.1 mg/ml
General Readings 1. Hazenberg, B et al; Immunohistochemical detection of Amyloid AA in formaline-fixed paraffin-embedded rectal biopsies with the monoclonal antibody anti-human SAA antibody Reu.86.2. Amyloid and Amyloidosis 1990, VIth International Symposium on Amyloidosis: 809.
2. Hazenberg, B et al; Monoclonal antibody based ELISA for human SAA. Amyloid and Amyloidosis, eds. LB Natvig et al, Kluwer Acad Publ 1990: 898
Wilkins, J et al; Rapid automated enzyme immunoassays of Serum Amyloid A. Clin Chem 1994, 40: 1284.
3. Hazenberg, B et al; A quantitative method for detecting deposits of amyloid A protein in aspirated fat tissue of patients with arthritis. Ann Rheum Dis 1999, 58: 96.
Storage

Store at 2 - 8 °C.
Shelf life: one year from despatch.

Format
Purification:
Protein G
Buffer System:
PBS
Preservatives:
0.02% sodium azide
Stabilizers:
0.1% bovine serum albumin
State:
Liquid 0.2 µm filtered Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, mouse
Specificity
Specificity:
This antibody reacts with the SAA-1 type.

Accessory Products

Proteins and/or Positive Controls

Proteins for Serum Amyloid A protein (SAA) (15 products)

Catalog No. Species Pres. Purity   Source  

Serum Amyloid A protein (SAA) (19-122, His-tag)

Recombinant human Serum amyloid A, 19-122 aa, His-tagged Human Purified > 95 % pure by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

Serum Amyloid A protein (SAA) (19-122, His-tag)

Recombinant human Serum amyloid A, 19-122 aa, His-tagged Human Purified > 95 % pure by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

Serum Amyloid A protein (SAA) (Apo-SAA1)

Serum Amyloid A protein (SAA) Human > 98 % pure by SDS-PAGE and HPLC analyses E. coli
  Acris Antibodies GmbH

Serum Amyloid A protein (SAA) (Apo-SAA1)

Serum Amyloid A protein (SAA) Human > 98 % pure by SDS-PAGE and HPLC analyses E. coli
  Acris Antibodies GmbH

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human > 98 % Greater than 98% by SDS-PAGE gel and HPLC analyses E. coli
  Acris Antibodies GmbH

Serum Amyloid A protein (SAA) (SAA1)

Serum Amyloid A protein (SAA) Human in vitro transl.
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA) (SAA1)

Serum Amyloid A protein (SAA) Human in vitro transl.
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA) (SAA2)

Serum Amyloid A protein (SAA) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA) (SAA2)

Serum Amyloid A protein (SAA) Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human
  Abnova Taiwan Corp.

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human > 96 % Serum
  BBI Solutions

Serum Amyloid A protein (SAA)

SDS-Page: Serum Amyloid A Protein [NBP1-30209] - Serum amyloid A, 13.9 kDa (125aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Human Purified
  Novus Biologicals Inc.

Serum Amyloid A protein (SAA)

Serum Amyloid A protein (SAA) Human Purified
  Novus Biologicals Inc.

Positive controls for Serum Amyloid A protein (SAA) (3 products)

Catalog No. Species Pres. Purity   Source  

SAA2 Lysate (SAA2)

Western Blot: SAA2 Lysate [NBL1-15672] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SAA2
  Novus Biologicals Inc.

Serum Amyloid A Lysate

Western Blot: Serum Amyloid A Lysate [NBL1-15670] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SAA1
  Novus Biologicals Inc.

Serum Amyloid A Lysate

Western Blot: Serum Amyloid A Lysate [NBL1-15671] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SAA1
  Novus Biologicals Inc.
  • LinkedIn