discontinued

NBP1-39965 SET / I2PP2A antibody

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Search for all "SET / I2PP2A"

0.05 mg / €410.00

Quick Overview

Rabbit anti Human SET / I2PP2A

NBP1-39965

Product Description for SET / I2PP2A

Rabbit anti Human SET / I2PP2A.
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for SET / I2PP2A

Product Category Primary Antibodies
Quantity 0.05 mg
Synonyms I-2PP2A, IGAAD, Inhibitor of granzyme A-activated DNase, PHAPII, Phosphatase 2A inhibitor I2PP2A, TAF-I, Template-activating factor I
Reactivity Hu
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
H0UI37
Immunogen:
Synthetic peptides of amino acids 66-81 and 135-151 of human INHAT-1. Sequence homology is 100% in mouse and rat.,
GeneID:
100130890
Add. information ,
Application This antibody is useful in Western Blot , Immunohistochemistry-Paraffin (10 ?g/ml)., Western Blot 1 - 2 ug/ml, Immunohistochemistry-Paraffin 10 ug/ml.
Background SET belongs to a family of multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. There are two named isoforms produced by alternative splicing : Isoform 1 and Isoform 2. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with NUP214/CAN.
Concentration 0.5 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
protein G purified
Buffer System:
PBS, 0.02% sodium azide, 0.1 mg/ml BSA. sodium azide is toxic.
Specificity
Specificity:
Synthetic peptides of amino acids 66-81 and 135-151 of human INHAT-1. Sequence homology is 100% in mouse and rat.,
Species:
Human
Gene ID 6418

Accessory Products

Proteins and/or Positive Controls

Proteins for SET / I2PP2A (6 products)

Catalog No. Species Pres. Purity   Source  

SET (1-290, His-tag)

SET Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

SET (1-290, His-tag)

SET Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

SET / I2PP2A

SET / I2PP2A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SET / I2PP2A

SET / I2PP2A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

TSTD3 (1-97, His-tag)

TSTD3 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €940.00
  Acris Antibodies GmbH

TSTD3 (1-97, His-tag)

TSTD3 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

Positive controls for SET / I2PP2A (2 products)

Catalog No. Species Pres. Purity   Source  

SET Lysate

Western Blot: SET Lysate [NBL1-15867] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SET
0.1 mg / €400.00
  Novus Biologicals Inc.

TSTD3 overexpression lysate

TSTD3 overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.
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