AP53869PU-N SF3B2 (Center) antibody

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0.4 ml / €370.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human SF3B2

Product Description for SF3B2

Rabbit anti Human SF3B2.
Properties: (Center)
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for SF3B2

Product Category Primary Antibodies
Quantity 0.4 ml
Synonyms SAP145, Splicing factor 3B subunit 2
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q13435
Immunogen:
KLH conjugated synthetic peptide between 515-545 amino acids from the Central region of Human SF3B2
GeneID:
10992
Property Center
Add. information Molecular Weight: 100228 Da
Application ELISA: 1/1,000.
Western blotting: 1/100-1/500.
Background This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq].
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration lot specific
General Readings
  1. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. PubMed PMID: 17525332.
  2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89. Epub 2007 Mar 13. PubMed PMID: 17353931. (Free PMC Article available, 9 images available)
  3. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. PubMed PMID: 17081983.
  4. Terada Y, Yasuda Y. Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145. Mol Cell Biol. 2006 Nov;26(21):8149-58. Epub 2006 Aug 21. PubMed PMID: 16923959. (Free PMC Article available, 5 images available)
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A column followed by peptide Affinity purification
Buffer System:
PBS with 0.09% (W/V) Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Specificity
Specificity:
Recognizes SF3B2 (Center).
Species:
Human.
Gene ID 10992

Accessory Products

Proteins and/or Positive Controls

Proteins for SF3B2 (1 products)

Catalog No. Species Pres. Purity   Source  

Splicing factor 3b, subunit 2, 145kDa (SF3B2)

Splicing factor 3b, subunit 2, 145kDa (SF3B2) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Positive controls for SF3B2 (1 products)

Catalog No. Species Pres. Purity   Source  

SF3B2 overexpression lysate

SF3B2 overexpression lysate
0.1 mg / €480.00
  OriGene Technologies, Inc.
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