TA320063 SHANK3 (Center) antibody

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0.1 mg / €325.00
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Rabbit anti Human, Mouse SHANK3

TA320063

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  • TA320063
  • TA320063

Product Description for SHANK3

Rabbit anti Human, Mouse SHANK3.
Properties: (Center)
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Immunocytochemistry/Immunofluorescence, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for SHANK3

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms PSAP2, ProSAP2, Proline-rich synapse-associated protein 2, SH3 and multiple ankyrin repeat domains 3, SPANK-2
Presentation Aff - Purified
Reactivity Hu, Ms
Applications E, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Immunogen:
19 amino acid synthetic peptide near the center of human SHANK3 (AP55426CP-N)
Property Center
Add. information Blocking peptide available: AP55426CP-N
Application Western blot: 1-2 µg/ml.
Positive Control: 3T3 cell lysate. 
Immunofluorescence: Start at 2.5 μg/ml. 
Immunohistochemistry on Paraffin Sections: Start at 2.5 µg/ml.
Background SH3 and multiple ankyrin repeat domains 3 (SHANK3), a member of the Shank gene family, plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
Concentration 1.0 mg/ml
General Readings
  1. Sheng M and Kim E. The Shank family of scaffold proteins. J. Cell Sci. 2000; 113:1851-6.
  2. Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, et al. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7. PubMed PMID: 12626503.
  3. Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, et al. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem. 1999 Oct 8;274(41):29510-8. PubMed PMID: 10506216.
  4. Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet. 2007 Jan;39(1):25-7. Epub 2006 Dec 17. PubMed PMID: 17173049. (Free PMC Article available, 2 images available)
  5. Bonaglia MC, Giorda R, Mani E, Aceti G, Anderlid BM, Baroncini A, et al. Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome. J Med Genet. 2006 Oct;43(10):822-8. Epub 2005 Nov 11. PubMed PMID: 16284256. (Free PMC Article available, 3 images available)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse.
Specificity
Specificity:
At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.

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