TA320063 SHANK3 (Center) antibody

Immunogen:

19 amino acid synthetic peptide near the center of human SHANK3 (AP55426CP-N)

1. Sheng M and Kim E. The Shank family of scaffold proteins. J. Cell Sci. 2000; 113:1851-6.
2. Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, et al. The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7. PubMed PMID: 12626503.
3. Lim S, Naisbitt S, Yoon J, Hwang JI, Suh PG, Sheng M, et al. Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem. 1999 Oct 8;274(41):29510-8. PubMed PMID: 10506216.
4. Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, et al. Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat Genet. 2007 Jan;39(1):25-7. Epub 2006 Dec 17. PubMed PMID: 17173049. (Free PMC Article available, 2 images available)
5. Bonaglia MC, Giorda R, Mani E, Aceti G, Anderlid BM, Baroncini A, et al. Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13.3 deletion syndrome. J Med Genet. 2006 Oct;43(10):822-8. Epub 2005 Nov 11. PubMed PMID: 16284256. (Free PMC Article available, 3 images available)

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Purification:

Affinity chromatography purified via peptide column

Buffer System:

PBS containing 0.02% Sodium Azide as preservative

State:

Liquid purified Ig fraction
Aff - Purified

Species reactivity (tested):

Human, Mouse.

Specificity:

At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.