NB120-3254 SHP 1 antibody

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Mouse anti Human SHP 1 1SH01 (11D7C8H5)


Product Description for SHP 1

Mouse anti Human SHP 1 1SH01 (11D7C8H5).
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for SHP 1

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications IP, WB
Clonality Monoclonal
Clone 1SH01 (11D7C8H5)
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Background SHP 1 is an SH2 containing protein tyrosine phosphatase 1 (SHP 1). SHP 1 is known to play a crucial role in the regulation of hematopoiesis and it regulates the transcriptional activity stimulated by the erythropoietin (EPO) induced JAK / STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis. Furthermore, the observation that SHP 1 associates with RAFTK / Pyk2 / CAK activated by beta chemokine receptor (CCR5) and SHP 1 also associates with the adaptor protein GRB 2 and the Src related kinase Syk indicates the role of SHP 1 in modulating cell migration, proliferation and immune functions.
General Readings General / background references:Ganju RK et al. Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem 275:17263-8 (2000). PubMed PMID: 10747947
Xie ZH et al. Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells. J Immunol 164:1521-8 (2000). PubMed PMID: 10640770
Bittorf T et al. SHP1 protein tyrosine phosphatase negatively modulates erythroid differentiation and suppression of apoptosis in J2E erythroleukemic cells. Biol Chem 380:1201-9 (1999). PubMed PMID: 10595583
Daws MR et al. H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97:656-64 (1999). PubMed PMID: 10457220
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein G purified
Cross-reacts with Human.Not yet tested in other species.

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