discontinued

NB100-55899 SIGIRR antibody

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0.1 mg / €420.00

Quick Overview

Rabbit anti Human, Mouse SIGIRR

NB100-55899

Product Description for SIGIRR

Rabbit anti Human, Mouse SIGIRR.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for SIGIRR

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Ms
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Murine SIGIRR (CT) peptide.
Background SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.
General Readings
  1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
  2. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
  3. Thomassen E, Renshaw BR, Sims JE. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 1999 Jun;11(6):389-99. PubMed PMID: 10346978.
  4. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003 Sep;4(9):920-7. Epub 2003 Aug 17. PubMed PMID: 12925853.
  5. Liew FY, Liu H, and Xu D. A novel regulator for IL-1 and Toll-like receptor 4. Immunol. Lett. 2005; 96:27-31.
Storage Store at 4C. Do not freeze.
Format
Purification:
Affinity purified
Buffer System:
PBS containing 0.02% sodium azide.
Purity:
Affinity purified
State:
Aff - Purified
Specificity
Species:
Human, Mouse Not yet tested in other species.

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