AM32902PU-N Siglec-H (50-100) antibody

See related secondary antibodies

Search for all "Siglec-H"

0.5 mg / €330.00

Quick Overview

Rat anti Mouse Siglec-H IMG23M15C8

Product Description for Siglec-H

Rat anti Mouse Siglec-H IMG23M15C8.
Properties: (50-100)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for Siglec-H

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation Purified
Reactivity Ms
Applications P
Clonality Monoclonal
Clone IMG23M15C8
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
A portion of amino acids 50-100 of Mouse Siglec-H
Property 50-100
Application Immunohistochemistry on Paraffin Sections: 5 μg/ml.
Background Siglec-H, or sialic acid binding immunoglobulin-like lectin H, is a CD33 related protein expressed specifically by plasmacytoid dendritic cells or pDCs (1, 2).  Antigen-mediated delivery by Siglec-H in pDCs inhibits Th cell proliferation and further antibody responses.  This leads to lessened expansion and Th1/Th17 polarization (3).  Constant and low density antigen presentation by Siglec-H is thought to lead to an exhaustive type lessening of the response in CD4+ cells but not tolerance.  A number of pathways have been proposed for the Siglec-H induced T cell hyporesponsiveness.  Ever decreasing activation cycles in the presence of low level but continuous antigen delivery, as that observed with Siglec-H, have also been demonstrated to impart FoxP3+ Tregs immunosuppressive tolerogen-like effects (4, 5).  Ability to identify and control Siglec-H antigen mediated delivery activities with specific antibody provides a focal point for potential development of inflammation controls.
Concentration 0.5 mg/ml
General Readings
  1. http://www.copewithcytokines.de/cope.cgi?key=SIGLEC-H__REFERENCES
  2. Loschko, J et al. 2011 Antigen targeting to Plasmycotid Dendritic Cells via Siglec-H inhibits Th-Cell-Independent Autoimmunity. J. Immunol 187 doi: 10-4019/jimmunol. 11 02307.
  3. Zhang J, Raper A, Sugita N, Hingorani R, Salio M, Palmowski MJ, et al. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood. 2006 May 1;107(9):3600-8. Epub 2006 Jan 5. PubMed PMID: 16397130.
  4. Apostolou I, von Boehmer H. In vivo instruction of suppressor commitment in naive T cells. J Exp Med. 2004 May 17;199(10):1401-8. PubMed PMID: 15148338. (Free PMC Article available, 5 images available)
  5. Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol. 2007 Jun 15;178(12):7849-58. PubMed PMID: 17548623.
Storage Store undiluted at 2-8°C.
This products is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Protein G Chromatography
Buffer System:
0.05% Sodium Azide
0.05% BSA
Liquid purified IgG fraction
This antibody recognizes Mouse Siglec-H.
Other species not tested.

Accessory Products

  • LinkedIn