discontinued

GTX22971 SIRP alpha antibody

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0.5 ml / €370.00

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Rabbit anti Human, Monkey SIRP alpha

GTX22971

Product Description for SIRP alpha

Rabbit anti Human, Monkey SIRP alpha.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for SIRP alpha

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Mky
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
A synthetic peptide corresponding to amino acids 476 - 503 (Cys-HLNRTPKQPAPKPEPSFSEYASVQVPRK) from the C terminal of human SHPS 1.
Application IHC-P, WB
Background SIRPs are heterophilic adhesive membrane glycoproteins with three extracellular Ig like domains and a cytoplasmic domain with two immunoreceptor with tyrosine based inhibition motifs that can interact with src homology 2 domain containing phosphatases. SIRP inhibit signaling through receptor tyrosine kinases. SIRP is selectively expressed by myeloid cells and neurons. SIRP ligation induces nitric oxide production by macrophages. p84 is involved in receptor tyrosine kinase signaling at synapses in the mammalian central nervous system (CNS) and in non neural tissues. P84 binds to the integrin associated protein (IAP / CD47) and they represent a heterophilic binding pair likely to be involved in bi directional signaling at the synapse and in other tissues.
Concentration 1 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Format
Purification:
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Purity:
Protein A purified
State:
Liquid
Purified
Specificity
Specificity:
Cross-reacts with Human and Monkey. Does not cross-react with Mouse. Not yet tested in other species.

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