NB120-2971 SIRP alpha antibody

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Rabbit anti Human, Monkey SIRP alpha


Product Description for SIRP alpha

Rabbit anti Human, Monkey SIRP alpha.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for SIRP alpha

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Mky
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide corresponding to amino acids 476 - 503 (Cys-HLNRTPKQPAPKPEPSFSEYASVQVPRK) from the C terminal of human SHPS 1.
Background SIRPs are heterophilic adhesive membrane glycoproteins with three extracellular Ig like domains and a cytoplasmic domain with two immunoreceptor with tyrosine based inhibition motifs that can interact with src homology 2 domain containing phosphatases. SIRP inhibit signaling through receptor tyrosine kinases. SIRP is selectively expressed by myeloid cells and neurons. SIRP ligation induces nitric oxide production by macrophages. p84 is involved in receptor tyrosine kinase signaling at synapses in the mammalian central nervous system (CNS) and in non neural tissues. P84 binds to the integrin associated protein (IAP / CD47) and they represent a heterophilic binding pair likely to be involved in bi directional signaling at the synapse and in other tissues.
General Readings General / background references:Jiang P et al. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274:559-62 (1999). PubMed PMID: 9872987
Veillette A et al. High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages. J Biol Chem 273:22719-28 (1998). PubMed PMID: 9712903
Stofega MR et al. Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association. J Biol Chem 273:7112-7 (1998). PubMed PMID: 9507023
Ottinger EA et al. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J Biol Chem 273:729-35 (1998). PubMed PMID: 9422724
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein A purified
Cross-reacts with Human and Monkey.Does not cross-react with Mouse.Not yet tested in other species.

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