GTX30308 SMC1 antibody

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0.1 mg / €420.00

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Rabbit anti Bovine, Mouse, Rat, Xenopus SMC1


Product Description for SMC1

Rabbit anti Bovine, Mouse, Rat, Xenopus SMC1.
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for SMC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Structural Maintenance of Chromosomes-1
Reactivity Bov, Ms, Rt, Xen
Applications C, IP, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Rabbits were immunized with a synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes-1 encoded within exon 26 (LocusLink ID 8243). Antibody was affinity purified using the peptide immobilized on solid support.
Application IHC, IP, WB
Background Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.
Storage Keep as concentrated solution, aliquot and store at 4
This antibody reacts with Homo sapiens. Other species have not been tested. Mouse, Rat and Bovine expected based upon sequence identity. Mismatches: Xenopus laevis 2 (1 conserved, one deletion.)

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