discontinued

GTX30309 SMC1 pSer957 antibody

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0.1 mg / €480.00

Quick Overview

Rabbit anti Human SMC1

GTX30309

Product Description for SMC1

Rabbit anti Human SMC1.
Properties: pSer957
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for SMC1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Structural Maintenance of Chromosomes-1
Reactivity Hu
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Rabbits were immunized with a phosphorylated synthetic peptide, which represented the portion of human Structural Maintenance of Chromosomes-1; (LocusLink ID 8243) around Serine 957. Antibodies that were not phospho-specific were removed by solid phase ab
Property pSer957
Application IP, WB
Background Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint
Storage Keep as concentrated solution, aliquot and store at 4
Format
State:
Liquid
Specificity
Specificity:
This antibody reacts with human SMC1 phosphoSerine 957. Other species have not been tested.

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