GTX21277 SMC3 (phospho S383) antibody

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50 µg / €370.00

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Rabbit anti Human SMC3 (phospho S383)


Product Description for SMC3 (phospho S383)

Rabbit anti Human SMC3 (phospho S383).
Presentation: Aff - Purified
Product is tested for Immunoprecipitation.

Properties for SMC3 (phospho S383)

Product Category Primary Antibodies
Quantity 50 µg
Presentation Aff - Purified
Reactivity Hu
Applications IP
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Rabbits were immunized with a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes-3 (LocusLink ID 9126)around Serine 383, conjugated to KLH. After multiple immunizations in Freund's adjuvant, serum
Application IP
Background Involved in chromosome cohesion during the cell cycle and in DNA repair. Central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.
Concentration 1 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Immunogen affinity purified
Buffer System:
Tris-citrate/phosphate, pH 7-8, 0.1% sodium azide
Immunogen affinity purified
Aff - Purified
Human - Not yet tested in other species

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