discontinued

GTX80846 Smoothelin antibody

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0.1 mg / €520.00

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Mouse anti Canine, Chicken, Feline, Human Smoothelin R4A

GTX80846

Product Description for Smoothelin

Mouse anti Canine, Chicken, Feline, Human Smoothelin R4A.
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Smoothelin

Product Category Primary Antibodies
Quantity 0.1 mg
Reactivity Can, Chk, Fe, Hu
Applications C, ICC/IF, WB
Clonality Monoclonal
Clone R4A
Host Mouse
Isotype IgG1
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Cytoskeletal smoothelin extract of chicken gizzard.
Application IF, IHC, WB
Background Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC-like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22.
Storage -20
Format
State:
100 ug of epitope affinity purified antibody (0.5 mg/ml) in PBS containing 0.1% sodium azide.
Specificity
Specificity:
Canine, Chicken, Feline, Human, Non-human primate

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