discontinued

NB120-3464 Sodium Channel antibody

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0.1 mg / €420.00

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Rabbit anti Human, Rat Sodium Channel

NB120-3464

Product Description for Sodium Channel

Rabbit anti Human, Rat Sodium Channel.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Sodium Channel

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Rt
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Peptide sequence: L(20)MKGNKREEQGLGPEPAAPQQPT(42) C.Immunizing peptide corresponds to amino acid residues 20-42 from human alpha-ENaC. This sequence is 82%, 73%, 64%, and 59% conserved in the rat and rabbit, mouse, guinea pig, and cow, respectively.
Background Epithelial sodium channels are amiloride-sensitive members of the Degenerin/Epithelial Sodium Channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel?s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
General Readings General / background references:Ishibashi K & Marumo F Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. Biochem Biophys Res Commun 245:589-93 (1998). PubMed PMID: 9571199
Barbry P & Hofman P Molecular biology of Na+ absorption. Am J Physiol 273:G571-85 (1997). PubMed PMID: 9316461
Format
Purification:
Immunogen affinity purified
Buffer System:
PBS, 1 mg/ml BSA and 0.05% sodium azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Human and Rat.Expected to cross-react with Rabbit, Mouse, Cow and Guinea pig due to sequence homology.Not yet tested in other species.

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